Antibacterial and antibiofilm activities of taxifolin against vancomycin-resistant S. aureus (VRSA)

Background and objective: The medicinal effects of flavonoids are widely described in the literature; however, their antimicrobial against antibiotic resistant bacteria yet to be highlighted. This study was aimed at investigating growth biofilm inhibitory taxifolin, a flavonoid, vancomycin-resistant Staphylococcus aureus (VRSA). Methods: Seven VRSA isolates were used assess antibiofilm influence taxifolin. agar-well diffusion method determine zones inhibition caused by resazurin-based microdilution technique minimum concentration. Crystal violet staining biomass biofilms formed microorganisms. GraphPad Prism software present data figures. Results: Taxifolin inhibited bacterial dose-dependent fashion reduced viability. It similarly attenuated production activity manner. Conclusions: Current findings suggest antibacterial taxifolin